This video, titled "Perlmutter," discusses Dr. David Perlmutter's research and advice on maintaining brain health and preventing cognitive decline. It highlights concerning findings about anti-amyloid drugs potentially accelerating brain atrophy and emphasizes that Alzheimer's can be seen as "type 3 diabetes" due to the brain's trouble using sugar for energy. The video strongly advocates for lifestyle changes, including diet, exercise, and stress management, as key strategies to reverse or slow cognitive decline, rather than relying solely on medication.
Key Takeaways
1
Anti-amyloid drugs, intended for mild cognitive impairment, have been shown to potentially accelerate brain volume loss and atrophy, making Alzheimer's symptoms appear earlier.
2
Alzheimer's disease is often referred to as "type 3 diabetes" because it is linked to the brain's inability to effectively use glucose for energy, even decades before symptoms appear.
3
Individuals with insulin resistance or type 2 diabetes are at a significantly higher risk for developing Alzheimer's disease due to impaired glucose metabolism in the brain.
4
Lifestyle changes, including diet, exercise, socialization, mental stimulation, and avoiding smoking and excessive drinking, are more impactful than genetics in preventing memory decline.
5
Strength training, specifically hand grip strength, is associated with larger hippocampus (memory center) and prefrontal lobe volume (executive function).
6
Walking approximately 9,800 steps daily can lead to a significant decrease (up to 50%) in the incidence of dementia.
7
Mental decline as we age is not inevitable; research shows we have control over brain health through diet, exercise, stress management, sleep, brain exercise, and toxin avoidance.
8
Key strategies for cognitive health include managing stress, ensuring adequate sleep, regular exercise (up to 50% risk reduction), and a low-carb diet with intermittent fasting.
9
Avoiding neurotoxins (dagens) like pesticides, herbicides, and fungicides, and engaging in brain-stimulating activities are crucial for preventing brain degradation.
10
Natural GLP-1 enhancers like intermittent fasting, protein-rich meals, psyllium fiber, coffee, and specific extracts and teas can support brain health.
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0:01
good morning and welcome to another
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edition of today's nutrition where we
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look at what is new in research what's
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hot in the news or any topic that can
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help us lose weight feel great or live
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longer better it's all about that Health
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span again bringing you the best from
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the opening session of my favorite
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conference the integrative healthc care
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Symposium and it was entitled Mind Over
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metabolism
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choosing brain health by one of my
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favorite Dr David pearlmutter he is
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called the empowering neurologist
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specializing in maximizing brain health
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and he's just a wonderful human being
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when I was a chair of the dieticians
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group I had him come speak at our annual
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conference uh you may know him from some
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of his best-selling books The Grain
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Brain brainwash the better Brain book
1:02
Brain maker and he presents the best
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research on Common Sense advice on stain
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sharp what to do what not to do today's
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show is going to be jam packed so you
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might want to get a pencil and paper
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could be a really important show for you
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so here are the highlights of his talk
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and he brought in tons of research so
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this was what a paper that uh was from
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neurology April 2023 by Alves and the
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title on it was accelerated brain volume
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lost caused by anti-a ameloid drugs so
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it was showing that the research on
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hippoc cample so that's like the memory
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center of the brain okay and whole brain
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atropy when on anti-a ameloid drugs
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they took people that had mild cognitive
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impairment and treated them with anti-
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beta ameloid drugs and what they saw was
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a regression or shrinking of brain
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volumes typical of Alzheimer's dementia
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8 months earlier than if they had been
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untreated that research shows
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frightening potential for these anti-
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beta ameloid Therapies
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you know long-term brain health
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accelerating brain atrophy faster worse
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so the conclusion from that study
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suggested that all those pharmaceutical
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companies that had con had conducted
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trials on these beta ameloid drugs
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should go back and look at the volume or
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look at the data on brain volume report
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the findings and release the data for
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research ERS to investigate so we can
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update our standard of
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care we may be doing a lot more harm in
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Daily medical practice with
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prescriptions that are really making
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things worse I mean you know one year on
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beta ameloid drugs and like they're
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eight months worse than if they hadn't
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been
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treated okay and that's this is like
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really important because there's an
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estimated 6.7 million Americans that are
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on uh or that have Alzheimer's and
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Alzheimer's we know begins 20 30 40
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years or more before memory loss or
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symptoms develop and we can tell that by
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brain scans way before it's noticeable
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to themselves or
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others now I'm going to switch gears a
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little bit and start the conversation
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about how the brain gets energy
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how we get energy to think to do things
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for more than 20 years I have heard in
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scientific C circles that Alzheimer's
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disease is really referred to as type 3
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diabetes and when I ask family members
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if their loved one with a diagnosis as a
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sweet tooth there's always a resounding
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yes with some eye rolling and if you're
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old enough to remember President Reagan
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and his jelly beans you're going to have
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a better understanding of this horrible
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decline with the disease starting with
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insulin
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resistance how many of us have insulin
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resistance there is a real energetic
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link science has observed the
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brain has low glucose
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metabolism decades before clinical
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manifestations of Alzheimer's so it
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really is considered untreated insulin
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resistance you know
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that individuals with insulin resistance
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or type 2 diabetes are at a huge
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increased risk for development of
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Alzheimer's brain scans of controls
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versus Alzheimer's are really different
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and it's all the glucose
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metabolism that's
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different and brain glucose
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metabolism decreases progressively with
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cognitive decline as the brain glucose
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metabolism gets worth so does the
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cognitive decline so one really popular
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therapy that's used is the ketogenic
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diet so that the brain can get an
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alternate fuel source instead of sugar
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since it's having trouble using sugar it
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goes to ketones okay and often MCT oil
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is used it started out with coconut oil
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but they've gotten more sophisticated
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now we use MCT oil so brain disturbance
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in brain insulin
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has research going way back and
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pearlmutter went back to 2016 and this
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is really cool the research looked at
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glp1 Agonist that are the huge weight
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loss drug right now and the effects on
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brain metabolism this is like eight
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years ago and if you go back to a couple
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weeks ago you're going to get some you
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know some interesting similarities here
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when I talked about The glp1 Agonist but
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this was a six-month Tri
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and it used glp1 Agonist and it showed a
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prevention in decline of brain glucose
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metabolism and remember that's a
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Hallmark for progression of dementia
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okay then there was another one uh
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Frontiers in aging Neuroscience May
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2016 all right that goes back a little
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bit different okay so this
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one conclusion they concluded that the
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glp1 treatment prevented decline in
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glucose metabolism and it was associated
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with synaptic dysfunction and disease
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Evolution you see it's all about how we
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handle
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sugar back January 2020 this was in the
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Journal of the American Medical
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Association and I've said this forever
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but the title of the whole Journal that
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month was in Alzheimer's research
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glucose metabolism takes center stage
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and I quote to slow or prevent dementia
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using drugs and lifestyle modification
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typically prescribed for metabolic
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disorders like diabetes and
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obesity is leading to questioning
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whether so-called amalo hypothesis may
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be flawed we know that so here it comes
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down to Lifestyle
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to show you how much more control you
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have overwhelmingly our results show
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that healthy lifestyle is associated
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with slower memory
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Decline and even people that are
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genetically susceptible to memory
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decline so this was British medical
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journal January
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2023 and there was association between
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healthy lifestyle and memory decline
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10year study population about 30,000
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people 46% women and even with the apoe4
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genetic status what happened is they
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evaluated on six different lifestyle
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areas diet exercise socialization mental
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stimulation smoking and drinking and
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they rated them as either favorable
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average or
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unfavorable independent of genetic
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status those with the most fav aable did
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best so it's not the genetics it's the
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epigenetics what we expose ourselves to
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what we do every day and this is cool
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now we're talking strength and so I'm
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back to the weight training and
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everything back on track this is going
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to get you going so the Journal of
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Alzheimer's December
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2022 muscle strength hand grip strength
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higher
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non-dominant hand grip strength so for
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most of us that's the left hand
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associated with larger hippocampus
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that's the memory Center and if you had
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a higher dominant hand grip so that's
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for most of us the right hand was a
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larger
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prefrontal frontal lob volume so you've
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got better executive functioning
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planning decision making and overall
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Frailty was associated with you know
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everything being less so I question how
10:04
does the skeletal muscle communicate
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with the brain in health and disease I
10:10
know that muscle is an endrin organ like
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all the glands I talk about in my book
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get out of hormone hell you know
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so muscle or pituitary pineal pancreas
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adrenal parathyroid ovaries testes
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thyroid turns out that little hormones
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called
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myocin are made and released by
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exercising muscle and they're the
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orchestrators of the whole body's
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benefits of exercise she there's just so
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much and and it's it totally takes the
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genetic
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apoe4 out of it this is one of my
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favorite studies uh Jamma neurology
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September
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2022 and it's is basically walking
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associated with daily step count and
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intensity with incidents of dementia
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about 80,000 adults living in the
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UK and what they found huge decrease
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like up to 50% decrease in
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dementia and about 9800 steps seem to be
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optimal you know I love to tie what
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Pearl mutter says with brisance research
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cuz they are both on The Cutting Edge of
11:30
treatment and prevention of brain
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disease and they're unwavering in their
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dedication and all the research is
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really showing that mental decline as we
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age isn't something you have to accept
11:44
it's possible to stay sharp according to
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the latest research we have control by
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paying attention to what
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causes the health to be destroyed in our
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brain it's diet it's exercise it's
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Stress Management management it's sleep
12:00
it's brain exercise it's toxin avoidance
12:04
dagens avoid them and the use maybe of
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special supplements or Foods yeah and a
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lot of this comes down to the aurvedic
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medicine like over 5,000 years ago and I
12:15
wrote about some of it in my book so
12:18
putting it all together giving you the
12:19
strategies to sh stay sharp cognitively
12:23
sharp to 100 and Beyond you know that's
12:25
what I say I want to live to be 100 know
12:27
I'm there and glad I'm there here's how
12:29
I intend to do it and I I guess I want
12:31
to encourage you to make the changes you
12:34
need to make so you can too because in
12:36
this day and age it's not going to
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happen by accident there are things we
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have to know things we have to do things
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we have to avoid and you can't start too
12:46
soon the brain stops growing at about
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age 25 and begins to shrink at
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35 and that rate increases exponentially
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at age 70 so if you don't do anything to
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prevent the
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degradation yikes what can I say you
13:07
can't start too soon and you know people
13:10
are looking for a magic pill and you
13:12
know there aren't any the good news
13:15
though according to a ton of research
13:17
it's it's diet and lifestyle okay so and
13:22
in the genetic less than 5 to 10% of the
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genes are really going to be played out
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so if even if you have the
13:30
apo4 status genetics May load the gun
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but what you do daily pulls the trigger
13:37
I think that's empowering you're in the
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driver's seat you know maybe park the
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car and walk so you get that 10,000
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steps every day key lifestyle areas you
13:49
know diet and lifestyle and it's not
13:51
just breson and pearl mutter but it's
13:54
doctors Dean and Aisha Shai there is
13:58
Mark Heyman Sarah godfried cat tupes an
14:02
Hathaway I mean these people I know a
14:05
lot of these people and they are amazing
14:08
the real deal so research is always way
14:11
ahead of how medicine practices and I'm
14:14
bringing you the stuff that is way ahead
14:17
it's it's probably 20 30 years
14:20
before medical standard medical
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practices are going to be using of this
14:25
but diet and lifestyle therapy is
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showing 80 to 8 84% people improve now
14:33
we're not just slowing the decline these
14:35
people go back to work they start new
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careers they reverse the decline the
14:41
earlier you start the better of course
14:44
no drug has shown Improvement just
14:47
slowing decline that isn't what I want
14:50
you know who wants to have 10 years of
14:52
Alzheimer's turn into 20 when you have a
14:54
good chance of reversing it I think
14:56
that's so exciting so we got a lot of of
15:00
things here that tie in number one got
15:04
to look at stress number two you got to
15:07
look at Sleep Number Three we talked
15:11
exercise huge as much as a 50% reduction
15:15
in risk and we're talking all kinds of
15:17
exercise number four diet in the tubes
15:21
trial that they found even a mild state
15:24
of ketosis resulted in even better
15:27
benefits so the number one Rec
15:29
recommendation is maybe start lowering
15:31
your carbs with an extended overnight
15:34
fast intermittent fasting lots of
15:37
colorful vegetables low to no grains no
15:41
sugar the Mediterranean diet you know
15:43
they say plant-based but we're not
15:45
talking lots of grains grains are
15:47
starches and they turn to sugar and they
15:49
cause metabolic havoc in a lot of people
15:51
number five avoiding the toxins labeled
15:55
dagens we're talking pesticides
15:57
herbicides fungicides toxic to the
16:00
nervous system that's how they work on
16:02
pests and brain exercise you know you
16:05
got to got to work that brain whether
16:08
you take up a new instrument whether you
16:11
learn new computer programs whether
16:14
you're doing
16:15
seduko you just want to get the brain
16:19
working more now there's some
16:22
supplements magnesium DHA from omega-3
16:26
folate vitamin D and you can can get
16:29
most of those in my my uh pure one daily
16:34
or and the barlines wonderful but then
16:37
there's some other things that
16:38
neotropics whole coffee fruit extract
16:41
turmeric curcumin my favorite spice ever
16:45
anti-inflammatory fabulous MCT oil plain
16:49
old coffee now here's a list of some of
16:52
those glp one Agonist the natural ones I
16:55
talked about a couple years ago a couple
16:56
weeks ago so we're talking intermittent
16:58
fasting
17:00
glp1 is increased by exercise by protein
17:03
Rich Meals by The Humble yet powerful
17:06
celum fiber coffee is a natural enhancer
17:11
of glp1 and then we've got the cow curb
17:14
an extract of hops that is a glp1
17:18
enhancer uh and then in a current study
17:20
we found berberine green or green or
17:23
black tea uh cinnamon Resveratrol all
17:26
influence glp1 lots of good g health so
17:30
eating organic eating lots of vegetables
17:32
maybe some probiotics and monitor your
17:35
progress on weight loss and muscle mass
17:39
building with a good quality scale woo a
17:43
lot there today so thanks for listening
17:46
to another edition of today's nutrition
17:48
I hope you learn something that will
17:50
help you or someone you love it's been
17:52
my pleasure to bring you this
17:54
groundbreaking information as always you
17:57
can listen to this and other shows on on
17:59
my website Deb for.com on YouTube or any
18:03
place you listen to
18:04
podcasts on my webinar I also have an
18:07
extensive webinar on this so have a
18:10
great day and do something really good
18:13
for yourself
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Perlmutter
Deb Ford DCN RDN
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May 8, 2024
18:15
We know that Individuals with insulin resistance or type 2 diabetes have increased risk for development of Alzheimer’s disease. Brain scans of control vs Alzheimer’s are very different and glucose metabolism is something that is greatly affected. In fact, brain glucose metabolism decreases progressively with cognitive decline and is directly associated with diabetes and insulin resistance.